Versatile Small-Volume Cell Disruption for Research

The Multi Cycle (MC) Cell Disruptor is Constant Systems’ most versatile solution for small-volume sample processing, offering exceptional precision and repeatability in a compact benchtop format.

With a footprint of approximately 500 mm², the MC fits comfortably on the lab bench, but achieves optimal ergonomics when paired with its custom-designed mobile trolley. The trolley positions the system at the ideal operating height and features full-swivel, lockable casters for safe, effortless movement.

The MC supports processing volumes from 0.5 mL to 40 mL per cycle, and is recommended for total volumes up to 80 mL. This makes it an ideal upgrade for users transitioning from smaller benchtop methods such as bead beating or sonication, while still requiring high-performance, pressure-based cell disruption.

Like all Constant Systems instruments, the MC benefits from the company’s precise and fully scalable hydraulic control technology, ensuring consistent pressure delivery from low-volume (0.5 mL) preparations all the way to industrial processing at 150 L/hour. This accuracy allows 99% of the sample to be processed at the set pressure, providing reproducible and reliable results—often in a single pass, even for challenging sample types.

The MC can operate in three processing modes, enabling flexible handling of a wide range of samples, including fluid, viscous, tissue, plant, and frozen materials.

Single Cycle (SC) Mode

Ideal for 0.5 mL–8 mL volumes and suitable for all sample types, including fluid, solid, frozen, tissue, and plant materials. SC Mode performs a complete disruption cycle in a single pass.

Multi Cycle (MC) Mode

Designed for 8 mL–40 mL per cycle, and recommended for total volumes up to 80 mL. MC Mode is ideal for fluid and re-suspended samples that require controlled, multi-step processing.

Re-Cycle (RC) Mode

Perfect for extremely tough organisms—such as Gram-positive bacteria, certain fungi, and specific algae species. RC Mode performs multiple passes automatically, without the need to manually collect and reintroduce the sample. Supports volumes up to 80 mL.

Key Features & Specifications

• Simple, quick, and intuitive to use
• Requires only a standard electrical supply—no compressed air or bottled gas
• No priming or purging required; air in the system is processed safely with no effect on sample quality
• Integrated stainless steel spill tray for accidental collection
• Digital pressure display with precise adjustment between 1–40 kpsi
• Capable of processing fluid, re-suspended, viscous, tissue, plant, and frozen samples
• Supplied collection cups can be transferred to ice or freezer for temperature control
• Constant Systems’ hydraulic control ensures consistent, repeatable performance, with 99% of the sample processed at the chosen pressure
• Fully contained operation for enhanced safety
• Easy cleaning options:
  • Flow-through cleaning: simply run cleaning media through the system
  • Manual cleaning: product-contact components can be removed for autoclaving or manual washing
• Product-contact materials include 316L stainless steel, F51 duplex (or equivalent), EPDM, GLF-PTFE, and PEEK 450G
• Unit dimensions: 475×510×455 mm (D×W×H)
• Unit weight: 110 kg
• Electrical connections: country-specific plug type; standard single-phase supply via C15 or C20 connection

Ready to optimize your cell disruption workflow?
Our team is here to guide you in selecting the right Constant Systems model and configuration for your application.

Questions? Contact our product managers for more information.